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超分子状结合亲和力-实现了有效的协同作用的癌症治疗

Jinfeng Zhou¹, Jiake Gu², Xiaohuan Sun¹

¹School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|February 21, 2024

概括

基拉尔纳米颗粒选择性地向癌细胞,增强药物输送和化疗-光热疗法. 而D-enantiomer的结合性和治疗效果明显高于L-enantiomer.

科学领域:

生物材料科学生物材料科学
超分子化学超分子化学
纳米医学是一种纳米医学.

背景情况:

超分子性对于生物系统中的选择性相互作用至关重要,影响疾病诊断和治疗.
了解性结合亲和力是优化治疗效率的关键.

研究的目的:

为增强癌症治疗开发超分子性纳米粒子 (WP5D/L-Arg+DOX+ICG).
为了研究从D/L-氨酸到支柱[5]arene的奇拉性转移对纳米粒子结合和治疗结果的影响.

主要方法:

在水中溶解的支柱[5]arene (WP5) 与D/L-arginine (D/L-Arg) 的非共价组合,以创建奇拉纳米粒子.
作为抗癌药物使用的多克索鲁比辛化物 (DOX) 和作为光热剂使用的绿色氨酸 (ICG) 的加载.
对纳米颗粒与脂质体的结合亲和力和体外/体内治疗疗效的评估.

主要成果:

WP5D-Arg纳米粒子与WP5L-Arg纳米粒子相比,对脂脂质体的结合力是WP5D-Arg纳米粒子的107倍.
酶选择性相互作用导致癌细胞中的向药物积累.
WP5D-Arg+DOX+ICG显著增强了化学光热协同疗法,瘤抑制率为99.4%,而WP5L-Arg+DOX+ICG的56.4%.

结论:

超分子性在实现高度选择性的相互作用和卓越的治疗结果方面发挥着关键作用.
开发的性纳米粒子为先进的癌症治疗提供了一个有前途的平台,强调了超分子性在生物应用中的重要性.

关键词:

奇拉性转移是一种转移.奇拉性特异性的细胞吸收.光热疗法是一种光热疗法.超分子性超分子性

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