从基础科学到临床实践:对当前牙周/真菌牙再生生物材料的审查
Angela De Lauretis1,2, Øystein Øvrebø1,2, Mario Romandini3
1Department of Biomaterials, Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, 0455, Norway.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|February 21, 2024
概括
牙周炎的治疗涉及骨缺陷的再生技术. 目前的生物材料表现出有限的成功,特别是在严重的病例中,需要进一步研究改善牙周再生疗法.
科学领域:
- 牙周病学 牙周病学
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
背景情况:
- 牙周炎是一种炎症性疾病,导致牙支组织的再吸收和潜在的牙损失.
- 对于骨内和裂缺陷的初始非手术治疗后,需要考虑再生手术.
研究的目的:
- 审查用于牙周再生的再生技术.
- 突出当前生物材料的局限性,并确定未来的研究方向.
主要方法:
- 一个MEDLINE数据库搜索确定了生物材料:生物制品 (血小板缩剂,水凝),骨移植和膜.
- 基于组成,机制和临床应用,对生物物质和骨移植进行批判性分析.
主要成果:
- 部分牙周再生可以在骨内和II类裂缺陷中实现.
- 完全封闭缺陷仍然很困难,而III类裂缺陷也带来了重大挑战.
- 目前没有一种生物材料具有功能性牙周再生的所有理想特性.
结论:
- 牙周炎需要先进的,有针对性的再生疗法.
- 建议改进临床研究设计和报告,遵守CONSORT 2010.
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