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Updated: Jul 2, 2025

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
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阿斯巴拉金-85稳定了Mycobacterium结核病CYP121A1中的一个结构性活跃地点水网

Christopher S Campomizzi1, Patil Pranita Uttamrao2, Jack J Stallone1

  • 1Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo, Buffalo, New York 14203, United States.

Biochemistry
|February 21, 2024
PubMed
概括

细胞染色体P450酶CYP121A1对于Mycobacterium结核病的生存至关重要. 通过突变破坏其活跃部位的水网络会使酶失活,从而揭示了它在药物开发中的重要性.

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