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使用便携式核磁共振 (NMR) 测量乳腺组织的乳腺密度:精度和准确性

Satcha Foongkajornkiat¹, Kamil Sokolowski², James Stephenson^3,4

¹School of Chemistry and Physics, Queensland University of Technology, Brisbane, Queensland, Australia.

Magnetic resonance in medicine

|February 21, 2024

概括

便携式NMR (pNMR) 准确量化乳腺组织的乳腺图像密度 (MD). 表面T2和扩散测量显示高精度和准确性,为MD评估提供无辐射替代方案.

科学领域:

生物医学工程生物医学工程
医疗成像医学成像
核磁共振是一种核磁共振.

背景情况:

乳腺扫描密度 (MD) 是乳腺癌的一个重要风险因素.
准确量化MD对于风险评估至关重要.
目前用于MD评估的方法通常涉及辐射暴露.

研究的目的:

评估单面便携式NMR (pNMR) 的精度和准确性,以量化切除的乳腺组织中的MD.
为了比较pNMR测量与既有黄金标准技术.

主要方法:

通过使用PNMR (明显T2,扩散,T1) 和黄金标准 (微观图谱[μCT],组织学[H&E]) 分析了45个乳腺组织探头.
相对组织含水量作为MD-相当的指标.
布兰德-阿尔特曼分析和相关性图表评估了方法之间的一致性.

主要成果:

使用明显T2放松和扩散的PNMR测量显示与H&E和μCT有很强的相关性.
对T2和扩散方法的偏差在2.6~2.8个百分点 (pp) 之间,而95%的置信区间约为7.5-13.1pp.
基于T1的PNMR测量显示可靠性较低.

结论:

表面T2和基于扩散的PNMR提供了精确的 (约. 10 pp) 和准确的 (大约. 3 pp) 量化乳腺组织扩展的MD.
pNMR是MD评估的一个有前途的无辐射模式.

关键词:

乳腺密度乳腺密度乳腺组织的组成.组合成像成像是一种复合成像.乳腺图像密度乳腺图像密度核磁共振是一种核磁共振.单面的便携式NMR射线是一种单面的NMR射线.

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相关概念视频

Applications Of NMR In Biology

Applications Of NMR In Biology

Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.