在移植受体中COVID-19感染后的长期结果
Kaitlyn L Freels1, Kapil K Saharia2, John W Baddley2
1Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Clinical transplantation
|February 21, 2024
概括
固体器官移植接受者 (SOTR) 的长期COVID-19结局显示频繁的再入院和显著的6个月死亡率. 移植功能障碍比排斥更常见,强调需要密切监测感染后的患者.
科学领域:
- 移植医学 移植医学
- 传染病 传染病 传染病
- 免疫学 免疫学 免疫学
背景情况:
- 固体器官移植接受者 (SOTR) 中COVID-19的长期结果没有得到充分的记录.
- 这项研究解决了SOTR中独特的COVID-19后续事件,包括再录取,拒绝,功能障碍,失败和死亡率.
研究的目的:
- 描述COVID-19感染后固体器官移植接受者的长期临床结果.
- 为了确定不良事件的频率,如异种移植排斥,功能障碍,失败和感染后180天内死亡.
主要方法:
- 一项回顾性队列研究对138名在2020年3月至2021年11月期间被诊断患有COVID-19的固体器官移植接受者进行了回顾性队列研究.
- 疾病严重程度使用NIH标准进行分类. 收集和分析了人口统计,临床特征,治疗和结果的数据.
主要成果:
- 在138名SOTR中,97人需要住院治疗,37.5%的重症患者在入院期间死亡. 在180天内,44.7%的幸存者经历了再入院,14.4%患有移植功能障碍,而7.2%经历了移植失败.
- 在最初感染后幸存下来的六个月死亡率为3.2%. 观察到的移植功能障碍比异位移植排斥更频繁.
结论:
- COVID-19感染导致固体器官移植接受者频繁再入院和显著的6个月死亡率.
- 移植功能障碍是一个比COVID-19后拒绝更常见的并发症. 感染后对SOTR进行密切跟踪至关重要.
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