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不分离的肝素:优化实验室监测,减少日常血液静止测试实践中不必要的干扰

Emmanuel J Favaloro¹, Leonardo Pasalic^2,3, Giuseppe Lippi⁴

¹Department of Haematology, Institute of Clinical Pathology and Medical Research, Sydney Centres for Thrombosis and Haemostasis, New South Wales Health Pathology, Westmead Hospital, Westmead, Australia; School of Dentistry and Medical Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, New South Wales, Australia; School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead Hospital, Westmead, New South Wales, Australia. emmanuel.favaloro@health.nsw.gov.au

Polish archives of internal medicine

|February 21, 2024

概括

未分离的肝素 (UFH) 是医院常用的常见抗凝剂. 本综述侧重于优化UFH治疗监测的实验室测试,并尽量减少其与其他测试的干扰.

科学领域:

临床化学临床化学
血液学血液学血液学
药理学药理学是指药理学的学科.

背景情况:

未分离的肝素 (UFH) 是一种在临床环境中广泛使用的抗凝剂.
它的应用包括血栓治疗/预防,维持体外电路通透性,以及用于实验室分析的抗凝样.
在医院中UFH的存在很常见,可能会影响实验室测试结果.

研究的目的:

在实验室测试中审查未分离的肝素在实验室测试中的作用.
为了优化UFH治疗的实验室监测.
在各种实验室测试中解决和克服UFH干扰.

主要方法:

对UFH应用和实验室相互作用的文献综述.
对UFH对血液静止和生化分析的影响的分析.
讨论干扰缓解策略的讨论.

主要成果:

UFH对抗凝血和样本处理至关重要,但可能会干扰实验室检测.
特定的实验室测试需要在存在UFH时仔细考虑.
现有方法可以监测UFH疗法并管理其干扰.

结论:

优化实验室测试对于有效的UFH治疗管理至关重要.
了解UFH的干扰机制有助于准确的诊断测试.
在实验室样本中管理UFH的策略对于患者护理至关重要.

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