乳腺细胞瘤流行病学:基于人口的研究 (瑞典)
Anna Bergström1, Hans Hägglund2, Anders Berglund3
1Department of Medical Sciences, Dermatology and Venereology, Uppsala University, Uppsala Akademiska Hospital, Uppsala, Sweden. anna.v.bergstrom@akademiska.se.
Acta oncologica (Stockholm, Sweden)
|February 21, 2024
概括
成年人中巨细胞瘤的发病率和患病率高于以前报告的. 虽然预后通常是有利的,但乳腺细胞炎患者面临的共同疾病负担比一般人群更大.
科学领域:
- 血液学 血液学 血液学
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 巨细胞症是一种罕见的疾病,涉及异常的巨细胞积累,导致各种症状.
- 它被分为系统性巨细胞瘤 (SM) 和皮肤性巨细胞瘤 (CM).
- 乳腺细胞瘤的确切流行病学尚不清楚.
研究的目的:
- 为了确定成年巨细胞瘤患者的发病率,流行率和整体存活率 (OS).
- 评估该人口中并发症的负担.
- 利用瑞典基于人口的登记册来获得全面的数据.
主要方法:
- 从2001年至2018年使用瑞典国家登记册识别的成年巨细胞瘤病例 (≥20岁).
- 采用了匹配的队列设计,将病例与五个无巨细胞瘤对照进行了比较.
- 分析了使用卡普兰-梅尔方法的整体存活率和通过查尔森并发症指数 (CCI) 的并发症负担.
主要成果:
- 确定了2,040例成人乳腺细胞瘤病例,年发病率为1.56/100,000,流行率为23.9/100,000.
- 与对照组相比,乳腺细胞瘤患者表现出较高的并发症负担和较低的整体存活期.
- 发病率和流行率估计超过了以前的研究.
结论:
- 该研究显示,瑞典的乳腺细胞瘤发病率和患病率高于此前估计的.
- 乳腺细胞炎通常有良好的预后,但患者经历了相当大的并发症负担.
- 限制包括潜在的报告不足和诊断代码不一致.
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