奇托聚乙烯基酒精) 甲基酸基用于组织工程支架
Nghia Le Ba Thai1, Henry T Beaman1, Megan Perlman1
1Department of Biomedical and Chemical Engineering, Syracuse Biomaterials Institute, and BioInspired Syracuse: Institute for Material and Living Systems, Syracuse University, Syracuse, New York 13244, United States.
本研究为组织工程提供可调整的奇托桑-多 (乙烯基酒精) 甲基酸基. 这些混合支架提供受控的降解和机械特性,支持细胞生长和更快的伤口愈合,具有抗菌功效.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 聚合物化学 聚合物化学
背景情况:
- 控制组织工程支架的降解和机械性能对于有效的愈合和组织形成至关重要.
- 水凝模仿细胞外基质,由于其可调节的特性,它们被广泛用作支架.
研究的目的:
- 开发一种混合天然/合成水凝平台,用于可调节的组织工程支架.
- 研究聚合物含量和光启动器类型对水凝特性的影响.
主要方法:
- 奇托和聚乙烯醇 (PVA) 经过甲基酸盐组的修改.
- 奇托桑PVA甲基酸基 (ChiPVAMA) 是使用Irgacure 2959 (I2959) 或烯-2,4,6-trimethylbenzoylphosphinate (LAP) 作为光启动剂进行合成的.
- 评估了水凝降解,机械特性,细胞活力,伤口愈合和抗菌活性.
主要成果:
- 根据聚合物含量和光启动器,ChiPVAMA水凝显示了可调节的降解速率和机械性能.
- 所有的水凝配方在2D划伤试验中加速了伤口的关闭,与布相比.
- 封装的NIH/3T3细胞在14天内保持了高活力 (~92%) .
- 含有更高基托桑含量的水凝表现出显著的抗菌活性.
结论:
- ChiPVAMA 水凝为组织工程支架提供可调和可降解的平台.
- 这些水凝支持细胞生长,并表现出抗菌性质,使它们适合各种组织再生应用.
更多相关视频
12:22Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
05:26Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
Published on: April 13, 2022
相关概念视频
Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview
[3,3] Sigmatropic Rearrangement of Allyl Vinyl Ethers: Claisen Rearrangement
Fiber Reinforced Concrete
Accelerated Curing of Concrete
Production of Alcohol
