一种非peptidomimetic HIV 蛋白酶抑制剂的临床前表征,具有改善的代谢稳定性

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Andrew Mulato1, Eric Lansdon2, Ron Aoyama3

  • 1Department of Virology, Gilead Sciences, Foster City, California, USA.

Antimicrobial agents and chemotherapy
|February 21, 2024
PubMed
概括

一种新的HIV蛋白酶抑制剂GS-9770显示出潜在的无增强性,每天一次的口服治疗. 这种试验性药物具有强烈的活性,并改善了对HIV-1的抗药性,从而有可能减少药物相互作用.

关键词:
艾滋病病毒 艾滋病病毒 艾滋病病毒抗逆转录病毒耐药性 抗逆转录病毒耐药性抗病毒药物是一种抗病毒药物.抗病毒药理学 抗病毒药理学发现药物的发现.药物动力学 药物动力学在临床前药物研究中.蛋白质酶蛋白质酶是一种蛋白质.

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