在急性缺血性中风患者中,LRG1和CD4+ T细胞,认知障碍和神经功能之间的关系
Xiao Cheng1,2, Hongen Wei1,2, Yi Liu1
1Department of Neurology, The Fifth Clinical Medical College of Shanxi Medical University (Fifth Hospital of Shanxi Medical University), Taiyuan, 030009, China.
Biomarkers in medicine
|February 21, 2024
概括
富含白的α-2糖蛋白1 (LRG1) 水平与特定的T细胞群相关,并预测急性缺血性中风患者的认知障碍和神经恢复不良. 较高的LRG1表明结果更差.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 心血管医学 心血管医学
背景情况:
- 急性缺血性中风 (AIS) 对神经功能和认知健康构成重大挑战.
- 包括Th17,Th2和调节性T细胞 (Tregs) 在内的T细胞子集在中风后的炎症反应中起着关键作用.
- 富含白的α-2糖蛋白1 (LRG1) 是一种涉及各种生物过程的蛋白质,但其在AIS中的作用尚未完全理解.
研究的目的:
- 研究患有AIS的患者中LRG1水平和CD4+T细胞子集之间的关联.
- 确定LRG1与认知障碍和AIS后神经功能恢复之间的关系.
主要方法:
- 血LRG1度使用ELISA测量了175名AIS患者在多个时间点 (基线,1日,7日,1月和3月) 的血LRG1度.
- 与LRG1水平相关的T细胞子集 (Th17,Th2,Treg) 进行了分析.
- 在中风后3个月评估认知功能和神经状态.
主要成果:
- LRG1水平与Th2和Treg细胞呈负相关性,与Th17细胞呈正相关性 (p < 0.05).
- LRG1度呈现出动态模式,从基线增加到第1天,然后在第3个月下降 (p < 0.001).
- 所有测量时间点的LRG1水平升高与3个月后认知障碍和神经功能低下的存在显著相关 (p <0.05).
结论:
- 在AIS患者中,LRG1与改变的T细胞配置,特别是减少的Th2和Treg细胞和增加的Th17细胞显著相关.
- LRG1作为一种潜在的生物标志物,可以预测经过急性缺血性中风后的认知障碍和亚最佳神经恢复.
- 这些发现凸显了LRG1在AIS免疫病理学中的作用及其对患者结果的影响.
关键词:
CD4+ T 细胞是 CD4+ T 细胞.这就是LRG1的重点.急性缺血性中风 脑卒中 严重的中风不同化的集群 4+ T 细胞认知障碍是一种认知障碍.富含白的α-2-甘氨蛋白1 是一种富含白的α-2-甘氨蛋白.神经功能 神经功能 神经功能更多相关视频
相关概念视频
Ischemic Stroke l: Introduction
Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology
An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke l: Introduction
A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Hemorrhagic Stroke ll: Pathophysiology
A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Transient Ischemic Attack l: Introduction
A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...


