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Updated: Jul 2, 2025

Optogenetic Phase Transition of TDP-43 in Spinal Motor Neurons of Zebrafish Larvae
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Published on: February 25, 2022

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RNA结合性质通过体内凝结物形成协调TDP-43的稳态

Natalie M Scherer1, Cindy Maurel1, Matthew S Graus2,3

  • 1Faculty of Medicine, Health & Human Sciences, Macquarie Medical School, MND Research Centre, Macquarie University, Sydney, NSW 2109, Australia.

Nucleic acids research
|February 21, 2024
PubMed
概括

TDP-43蛋白形成类似液体的核凝聚物,对运动神经元功能至关重要. 由于突变或修改的异常凝结会导致神经退行性疾病,如ALS.

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