我们是否应该将系统性炎症反应指数 (SIRI) 作为直肠癌的新诊断标志物?
Hilmi Yazici1, Ayse Eren Kayaci2, Halil Ibrahim Sevindi2
1Marmara Universitesi Pendik Eğitim Ve Araştırma Hastanesi, Istanbul, Turkey. hilmiyazici@hotmail.com.
Discover oncology
|February 21, 2024
概括
系统性炎症反应指数 (SIRI) 可以帮助诊断直肠癌并预测患者的结果. 较高的SIRI水平表明预后较差,并发症增加,需要进一步研究.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 手术瘤学手术瘤学
背景情况:
- 系统性炎症反应指数 (SIRI) 是各种癌症的预后指标.
- 使用外围中性粒细胞,单细胞和淋巴细胞计数来计算SIRI.
研究的目的:
- 评估SIRI在直肠癌中的诊断价值.
- 评估SIRI对直肠癌患者预后影响.
主要方法:
- 对104名直肠癌患者医疗记录 (2017-2022) 的回顾性分析.
- 从手术前的外周血液计数计算出SIRI;最佳切断点在1.38.
- 基于SIRI组分析的临床病理结局和整体存活率 (OS) (≤1.38对>1.38).
主要成果:
- 在直肠癌患者中,SIRI的中位数明显高于对照组.
- 较高的SIRI组 (≥1.38) 有更多的男性患者和明显更高的并发症率 (p=0.004).
- 在低SIRI组 (≤1.38) 中,整体存活率更好.
结论:
- SIRI显示出作为直肠癌诊断标记物的潜力.
- 较高的SIRI水平与预后较差和并发症增加相关.
- 建议对更大的队列进行进一步的前性研究.
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