作为Bifidobacterium animalis亚种的辅助疗效. 乳糖XLTG11用于儿童功能性便秘
Ke Chen1, Zengyuan Zhou2, Yang Nie3
1Department of Nutrition, School of Medicine, Chengdu Women's & Children's Central Hospital, University of Electronic Science and Technology of China, Chengdu, China. kechen@uestc.edu.cn.
概括
生物细菌 (Bifidobacterium animalis) 的亚种. 乳糖XLTG11在功能性便秘的儿童中显著改善了便频率. 这种益生菌干预也导致了有益的肠道微生物群转变,并调节了关键的代谢途径.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 微生物组研究 微生物组研究
- 益生菌治疗药物 益生菌治疗药物
背景情况:
- 功能性便秘 (FC) 显著影响儿童的身体和精神健康.
- 目前针对儿童FC的治疗方法需要进一步优化,以提高疗效和安全性.
研究的目的:
- 为了评估Bifidobacterium animalis亚种的疗效和安全性. 乳糖XLTG11在治疗儿童功能性便秘.
- 调查XLTG11对便肠道微生物群组成和功能的影响.
主要方法:
- 一项随机,双盲,安慰剂对照试验与被诊断患有FC的儿童进行.
- 参与者接受了XLTG11 (干预组) 或安慰剂 (对照组) 的常规治疗.
- 便频率是主要结果;使用16S rRNA测序和PICRUSt.分析了肠道微生物群和基因家族丰度.
主要成果:
- 干预组的每周便频率明显高于干预后的对照组.
- 肠道微生物群的分析显示,干预组中出现了转向Bifidobacterium longum,Bifidobacterium breve和大肠杆菌的转变.
- 皮克鲁斯特的分析表明,短链脂肪酸 (SCF) 代谢基因的上调和甲代谢基因的下调.
结论:
- 每天使用Bifidobacterium animalis亚种的每日用量. 乳糖XLTG11 (1 × 10^10 CFU/天) 是有效和安全的改善便频率的儿童与FC.
- XLTG11促进肠道微生物群的有益变化,并调节关键的代谢途径,包括SCF和甲代谢.
- 这种益生菌为治疗儿科功能性便秘提供了一个有前途的治疗选择.
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