败血症后精神障碍:病理生理学,预防和治疗
Dayong Li1,2, Xujie Zhang2, Yuru Lu1,2
1Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
概括
败血症后精神障碍很常见,并增加死亡率. 了解其复杂的原因和可修改的风险因素是制定有效的预防和治疗策略的关键.
科学领域:
- 关键护理医学 关键护理医学
- 神经科学是一个神经科学.
- 精神病学是一种精神病学.
背景情况:
- 败血症后精神障碍,包括焦虑,抑郁,PTSD和妄想,是败血症的一个普遍并发症.
- 这种疾病显著增加了长期死亡率,但经常被临床医生忽视.
- 最近的研究强调,需要更好地理解和管理这些精神健康问题,在败血症后.
研究的目的:
- 审查了解败血症后精神障碍病理生理学的最新进展.
- 总结有关预防和治疗败血症后精神健康状况的当前知识,包括与COVID-19相关的知识.
- 为了强调解决这个经常被忽视的并发症的重要性.
主要方法:
- 本综述综合了关于败血症后精神障碍的最新科学文献.
- 它检查了复杂的病理生理学,包括血脑屏障,HPA轴,神经炎症和氧化应激.
- 确定可修改的风险因素,并讨论当前和潜在的治疗方法.
主要成果:
- 病理生理学包括神经炎症,氧化应激,神经递质功能障碍和神经可塑性受损.
- 可修改的风险因素包括创伤记忆,ICU停留时间,白蛋白水平,血管压缩剂使用和日常活动.
- 没有统一的诊断标准,但使用查尺度;建议针对风险因素进行有针对性的干预.
结论:
- 败血症后精神障碍是一种严重的并发症,需要更多的临床关注.
- 针对可修改的风险因素提供了一个有前途的预防策略.
- 诸如综合护理等非药物干预措施显示出潜力,而药物治疗需要进一步的临床验证.
相关概念视频
01:27Post-traumatic Stress Disorder
34
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
34
01:27Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
642
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
642
01:26Psychosis: Goals of Pharmacotherapy
130
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
130
01:30Psychosurgery
55
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
55
01:24Treatment Strategies for Psychological Disorders
129
Treatment approaches for psychological disorders fall into three main categories: psychological, biological, and sociocultural. Each approach targets different aspects of mental health, requiring varying levels of education and training.
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
Psychological therapies focus on modifying emotions, thoughts, and behaviors through talking, interpreting, listening, rewarding, challenging, and modeling. Clinical psychologists, counselors, and social workers commonly practice psychotherapy. Clinical...
129
01:30Pneumonia V: Nursing management and Prevention
2.1K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.1K