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中东植物对肺癌细胞具有强大的细胞毒性作用

Jilan A Nazeam¹, Soad Z El-Emam²

¹Department of Pharmacognosy, Faculty of Pharmacy, October 6 University, Giza, Egypt.

Journal of medicinal food

|February 21, 2024

概括

药用植物显示出对肺癌的承诺. 来自Taraxacum officinale和Ziziphus spina的提取物显示出强烈的细胞毒性作用,诱导细胞亡和细胞循环停止,具有作为补充肺癌治疗的潜力.

科学领域:

植物化学和药理学
自然产品化学化学
癌症研究癌症研究

背景情况:

癌症仍然是全球主要的死亡原因,化疗具有显著的副作用.
药用植物为新型抗癌药物发现提供了一个巨大的,尚未探索的资源.
世界卫生组织承认药用植物是药物的主要来源.

研究的目的:

选中东部植物提取物对抗人类肺癌细胞系的细胞毒性活动 (A549).
为了识别和描述来自选定的植物物种的强效抗癌化合物.
研究有前途的植物成分对癌细胞的作用机制.

主要方法:

对20种中东植物提取物进行了针对A549肺癌细胞的细胞毒性选.
生物活性提取物用绝对乙醇的分级沉法被分化.
细胞循环分析和细胞亡测定是在用活性成分治疗的癌细胞上进行的.

主要成果:

十一种植物提取物表现出显著的细胞毒性作用 (IC50<25μg/mL).
原始多糖沉物 (FA) 和过物 (FB) 显示出强烈的活性,其中Taraxacum officinale的FA (IC50 = 0.2μg/mL) 和Ziziphus spina的FB (IC50 = 0.1μg/mL) 是最有效的.
用这些分量的治疗诱导了G1/S相停止和细胞亡,这表明有计划的细胞死亡.

结论:

塔拉克萨 (Taraxacum officinale) 和齐齐 (Ziziphus spina) 的分离物对肺癌具有显著的细胞毒性潜力.
这些植物衍生分数主要通过亡诱导癌细胞死亡.
已识别的部分代表了对肺癌管理的补充或替代治疗策略的有希望的候选人.

关键词:

亚纳斯塔蒂卡是指一个高层的阴影.阿尔特梅西亚草药 (Artemisia herba) 是一种植物.塔拉克萨库姆 (Taraxacum officinale) 是一个官方的植物.这种植物是Ziziphus spina.灭症 (apoptosis) 是一种死亡的过程.细胞循环中的细胞循环.

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