在患有癌症的患者中进行类固醇肌肉病变和康复
Vera Tsetlina1, Ray A Stanford2, Grigory Syrkin3
1Department of Rehabilitation and Regenerative Medicine, NewYork-Presbyterial Columbia Irving Medical Center, New York, New York, USA.
PM & R : the journal of injury, function, and rehabilitation
|February 21, 2024
概括
葡萄糖皮质类固醇诱导肌肉病变 (SM) 是类固醇治疗的常见副作用. 运动疗法,特别是轻度至中度强度的运动疗法,可以帮助减少MS患者的肌肉分解.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 血液学 血液学 血液学
- 运动生理学 运动生理学
背景情况:
- 类固醇在癌症治疗中被广泛使用,但可以引起诸如类固醇诱导肌肉病 (SM) 等不良影响.
- 目前,没有确定的指导方针来诊断和治疗MS.
- 接受神经瘤治疗或输血造血干细胞移植的患者特别容易患MS.
研究的目的:
- 提供有关类固醇诱导肌肉病 (SM) 的最新信息.
- 专注于神经瘤学和干细胞移植患者的MS.
- 审查运动治疗作为对MS的潜在干预措施.
主要方法:
- 一个全面的叙事回顾SM的病因学,发病,发病率,临床表现和治疗方法.
- 对SM运动治疗的体内研究进行范围审查.
- 对24项研究的分析,这些研究调查了在葡萄糖皮质类固醇治疗期间的各种运动方式.
主要成果:
- 在24项研究中,有20项研究表明,运动训练会减少肌肉代谢.
- 轻度至中度强度的耐力和阻力运动被发现是有益的.
- 高强度运动的有效性仍然不确定,可能会加剧肌肉缩.
结论:
- 康复干预措施,包括运动,以及药物和饮食策略,可以帮助预防或逆转MS.
- 潜在的不良事件和将临床前发现转化为人类环境的局限性需要进一步的受控临床研究.
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