上皮上腺癌:分子发病,治疗选择,新兴的免疫疗法和向治疗方法
Divya Chukkalore1, Kira MacDougall2, Viraj Master3,4
1Department of Internal Medicine, Staten Island University Hospital, New York, NY, USA.
The oncologist
|February 21, 2024
概括
皮上腺癌 (ACC) 是一种罕见的癌症,预后不佳. 本综述涵盖了ACC流行病学,分子驱动因素和多学科管理,包括像免疫疗法这样的新兴疗法.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 皮上腺癌 (ACC) 是一种罕见的,具有侵略性的内分泌恶性瘤,预后不佳,特别是在晚期.
- 了解它的流行病学和分子病原性对于改善患者的治疗结果至关重要.
研究的目的:
- 为了提供对上腺皮层癌 (ACC) 的全面概述.
- 总结目前关于ACC流行病学,分子病变发生,临床表现,诊断和管理的知识.
- 为突出ACC新兴的治疗策略.
主要方法:
- 这是一个叙事评论.
- 在流行病学,分子致病,临床方面和ACC治疗方面的文献搜索.
- 主要发现和正在进行的研究的总结.
主要成果:
- ACC表现出复杂的分子信号通路,驱动其病变发生.
- 目前的管理涉及到一个多学科的方法,与正在进行的关于辅助性米托和建立的化疗方案的辩论.
- 新兴的向疗法和免疫检查点抑制剂对先进的ACC表现有前途.
结论:
- ACC需要一个多学科的方法,以实现最佳管理.
- 新型治疗策略,包括向疗法和免疫疗法,为晚期ACC患者提供了新的希望.
- 持续的研究和临床试验对于进一步改善ACC治疗结果至关重要.
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
Cancer Vaccines
367
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
367
Cancer
48.5K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
48.5K
Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K


