在COVID-19中,在清醒时倾向于定位的肺阻抗变化. 一个非随机交叉研究
Jacob Rosén1, Peter Frykholm1, Malin Jonsson Fagerlund2,3
1Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, Uppsala University, Uppsala, Sweden.
PloS one
|February 21, 2024
概括
醒着易感定位 (APP) 暂时增加了COVID-19患者的肺部招募,通过电气肺阻抗断层扫描 (EIT) 测量. 通风分布没有变化,表明APP APP.
科学领域:
- 关键护理医学 关键护理医学
- 呼吸系统生理学 呼吸系统生理学
- 医疗成像医学成像
背景情况:
- 清醒易感定位 (APP) 用于COVID-19患者的缺血性呼吸衰竭.
- 它对呼吸机制的确切影响,特别是肺体积和通风分布,仍然不完全理解.
- 电气肺阻抗断层扫描 (EIT) 为区域肺部评估提供了一种方法.
研究的目的:
- 在APP期间调查全球和区域肺体积的变化.
- 为了比较APP中的呼吸机制与使用EIT的仰卧姿势.
- 评估APP对COVID-19患者的通风分配的影响.
主要方法:
- 在瑞典两所大学医院进行的探索性,非随机交叉研究 (2021年1月至5月).
- 包括10名患有COVID-19的ICU患者,缺血性呼吸衰竭,并接受高流量鼻氧或非侵入性通风.
- EIT数据记录在卧卧的基线,在APP (30分钟和60分钟) 期间,以及回到卧卧状态后.
主要成果:
- 清醒易感定位 (APP) 导致全球和区域三角洲末呼吸肺阻抗 (dEELI) 显著增加,这表明肺部招募.
- 在全球或区域潮阻抗变化 (TIV),通风中心 (CoV) 或全球不均质 (GI) 指数中没有观察到显著变化.
- 观察到的肺部招募效应是暂时的,在重新定位到仰卧后恢复到基线.
结论:
- 醒着易感定位 (APP) 在COVID-19患有缺血性呼吸衰竭的患者中表现出暂时的肺部招募效应.
- 在APP期间,EIT的测量结果显示,通风分布没有显著变化.
- 在这种患者群体中,APP可能会促进肺部招募,而不会改变呼吸模式.
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