维生素D和在体外受精周期中的卵泡招募
Roberto de A Antunes1,2, Brenda M L de Melo1, Maria do Carmo B de Souza2
1Gynecology Department of the Clementino Fraga Filho University Hospital - Federal University of Rio de Janeiro - Rio de Janeiro - RJ, Brazil.
JBRA assisted reproduction
|February 21, 2024
概括
这项研究发现,维生素D水平与IVF过程中检索的卵细胞数量之间没有联系. 维生素D的充足或缺乏不会影响接受生育治疗的女性的卵巢刺激结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 营养科学 营养科学
背景情况:
- 维生素D (VD) 对骨健康至关重要,但其在女性生殖中的作用尚未完全理解.
- 维生素D受体 (VDR) 存在于女性生殖系统中,这表明它可能对生育能力产生影响.
- 在试管婴儿中,卵巢刺激的目的是最大限度地提高卵细胞的回收率,影响这一过程的因素具有显著的兴趣.
研究的目的:
- 为了研究血清维生素D水平和在接受试管婴儿的妇女在卵巢刺激后检索的卵细胞数量之间的联系.
- 为了确定维生素D状态 (缺乏与充足) 是否会影响卵巢刺激的关键结果.
主要方法:
- 在一家私人生育诊所接受试管婴儿治疗的267名患者的回顾性分析.
- 根据血清维生素D水平,患者被分为两组:<30 ng/mL (缺乏) 和>30 ng/mL (充足).
- 分析的数据包括年龄,人体测量,卵巢储备标记,淋巴激素剂量和卵泡数量.
主要成果:
- 在维生素D缺乏和充足的患者之间,检测到的卵泡或卵细胞数量没有统计学上显著的差异.
- 在卵巢刺激后获得的成熟卵细胞的数量在两个维生素D水平组中都是可比的.
- 血清维生素D水平似乎没有影响这个IVF队列中检索的卵细胞数量.
结论:
- 血清维生素D水平似乎不会影响卵泡数量,取出的卵细胞或在IVF卵巢刺激期间获得的成熟卵细胞.
- 进一步进行高质量的研究是有必要的,以探索维生素D在人类生殖的其他方面可能的作用.
- 研究结果表明,用血清水平测量的维生素D状况可能不是在试管婴儿中卵巢刺激成功的关键因素.
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