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庞丁NPS表达神经元在睡眠调节中的不同作用

Lijuan Xing¹, Xianlin Zou¹, Chen Yin¹

¹Department of Neurology, University of California San Francisco, San Francisco, CA 94143.

Proceedings of the National Academy of Sciences of the United States of America

|February 21, 2024

概括

神经S (NPS) 神经元在睡眠调节中具有双重作用. 一些NPS神经元促进清醒,而另一些神经元,特别是在马的中央灰色中,诱导睡眠.

科学领域:

神经科学是一个神经科学.
睡眠医学睡眠医学
分子生物学分子生物学

背景情况:

神经S (NPS) 以其潜在的唤醒促进特性而闻名,但其精确的机制和在睡眠-觉醒调节中的电路级功能仍然在很大程度上是未知的.
NPS受体 (NPSR1) 的遗传变异与人类睡眠持续时间的表型有关,突出显示了该途径在睡眠中的重要性.
了解不同的NPS表达神经元群体的特定作用对于破译睡眠-清醒控制至关重要.

研究的目的:

阐明不同表达神经S (NPS) 的神经元群体在调节睡眠和清醒中的特定功能.
研究NPS-NPSR1信号通路对睡眠-清醒调节的贡献.
区分NPS+神经元在各种大脑细胞核中的作用,包括对细胞核 (PB),周围 (peri-locus coeruleus,peri-LC) 和中部灰色的 (CGPn).

主要方法:

利用功能丧失和化学遗传方法来评估操纵NPS+神经元活动对睡眠和清醒状态的影响.
采用纤维光度测量来记录不同睡眠-清醒阶段NPS+神经元的活动.
进行了NPS-NPSR1信号封锁和基因淘汰 (Nps) 实验,以确认途径的参与.

主要成果:

在准臂核 (PB) 中的NPS+神经元被确定为唤醒促进神经元.
发现马的中央灰色 (CGPn) 中的NPS+神经元强烈促进睡眠,表现出唤醒活跃的发射模式.
周围部位 (peri-locus coeruleus,peri-LC) 中的NPS+神经元在睡眠-清醒调节中没有显著参与,尽管它们在清醒和REM睡眠期间活跃.

结论:

神经S (NPS) 及其相关的神经元在调节睡眠和清醒方面表现出二分化的作用,通过不同的神经回路起作用.
在分子和电路层面上,NPS-NPSR1通路在调节睡眠和清醒状态方面发挥着至关重要的作用.
在不同大脑区域的特定NPS+神经元群体以不同的方式控制睡眠和唤醒.

关键词:

国家安全系统 (NPS) 是一个国家安全系统.斯的中央灰色.神经电路的神经电路.一个副手臂核核.睡眠睡眠睡眠睡眠睡眠

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