相关实验视频

Updated: Jul 2, 2025

Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers
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Identifying Amino Acid Overproducers Using Rare-Codon-Rich Markers

Published on: June 24, 2019

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特定的编码子控制细胞资源和健康状况

Aaron M Love1,2, Nikhil U Nair2

  • 1Manus Bio, Waltham, MA 02453, USA.

Science advances
|February 21, 2024
PubMed
概括

优化基因表达需要仔细的编码子选择. 这项研究引入了Codon健康指数 (CHI),用于管理细胞资源,并防止多基因表达期间的宿主负担.

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The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the...
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