代谢综合征及其与精神分裂症,精神分裂症和双相情感障碍的抗精神病药物多种药物的关系
Karim Abdel Aziz1, Hind Mohd Ahmed2, Emmanuel Stip1,3,4
1Department of Psychiatry, College of Medicine and Health Sciences, United Arab Emirates University.
International clinical psychopharmacology
|February 21, 2024
概括
抗精神病多种药物并没有显著增加精神分裂症,精神分裂症或双相情感障碍患者的代谢综合征风险. 扩张性血压和 olanzapine 的使用是代谢综合征的关键预测因素.
科学领域:
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗精神病药物与代谢综合征 (MetS) 风险有关.
- 关于精神分裂症,精神分裂症和双相情感障碍患者接受抗精神病药物多药治疗的MetS的数据有限.
研究的目的:
- 调查精神分裂症,精神分裂症和双相情感障碍患者中MetS的患病率,这些患者接受抗精神病单疗法与多药治疗.
主要方法:
- 在833名患者中进行了横截面研究 (2017-2020年).
- 收集关于抗精神病药物类型,数量和使用的数据.
- 使用美国临床内分泌学协会标准诊断的MetS.
主要成果:
- 整体的MetS患病率为28.6%.
- 单疗法 (68.8%) 和多疗法 (31.2%) 组之间的MetS率没有显著差异.
- 扩张性血压和 olanzapine 的使用是 MetS 的显著预测因素.
结论:
- 抗精神病单疗法和多疗法显示了类似的MetS率.
- 特定的因素,如透静血压和奥兰扎平,可以预测MetS.
- 强调仔细选择抗精神病药物和代谢监测.
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