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固体器官移植接受者皮肤状细胞癌的结果:一个匹配的回顾性队列研究
Trent D Walker1, Yi-Tin Liao1, Melica Nikahd2
1College of Medicine, The Ohio State University, Columbus, Ohio.
概括
患有皮肤状细胞癌 (CSCC) 的固体器官移植接受者并不面临较高的不良结果风险. 在控制其他变量时,移植状态不是CSCC复发或死亡的独立风险因素.
科学领域:
- 在瘤学瘤学.
- 移植手术 移植手术
- 皮肤病学 皮肤病学
背景情况:
- 固体器官移植接受者患有皮肤状细胞癌 (CSCC) 历史上面临着不良结果的风险增加.
- 最近的证据表明,免疫抑制可能不是CSCC不良结果的独立风险因素.
研究的目的:
- 确定移植状态是否是CSCC患者不良结果的独立风险因素.
- 为了比较移植接受者和对照者之间局部复发,转移和疾病特异性死亡的风险.
主要方法:
- 在一个学术中心10年来对待的CSCC病例的回顾性队列研究.
- 基于年龄,瘤阶段,性别,瘤部位和结果的时间,对实体器官移植接受者 (n=78) 和对照组 (n=262) 的匹配比较.
- 多变量分析,以评估不良结果的风险因素.
主要成果:
- 瘤阶段和头部和部位置被确定为CSCC中不良结果的独立预测因素.
- 在移植受体组和对照组之间,没有观察到不良结果风险的显著差异.
- 分析包括来自移植患者的316个瘤和来自对照组的316个瘤.
结论:
- 移植状态不是皮肤状细胞癌的不良结果的独立风险因素.
- 当调整关键变量时,结果主要受瘤阶段和位置的影响,而不是移植状态.
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