子宫内膜癌的种族差异:26年后,我们在哪里?
Michael L Hicks1, Maya M Hicks2, Roland P Mathews3
1St. Joseph Mercy Oakland Cancer Center, Michigan Cancer Institute, 44405 Woodward Ave, Suite 202, Pontiac, MI 48324, USA; University of North Carolina at Chapel Hill, Department of Obstetrics & Gynecology, Chapel Hill, 101 Manning Dr. Chapel Hill, NC 27514, USA.
Gynecologic oncology
|February 21, 2024
概括
在非裔美国人和白人美国女性之间,子宫内膜癌发病率和死亡率的种族差异已经扩大,尽管进行了26年的研究. 目前的研究不足以弥补这一差距.
科学领域:
- 妇科瘤学 妇科瘤学
- 健康差距 研究 研究 研究 研究
- 流行病学 流行病学
背景情况:
- 子宫内膜癌是美国最常见的女性生殖道恶性瘤.
- 几十年来,子宫内膜癌的结果存在显著的种族差异.
- 以前的研究已经广泛调查了这些差异超过26年.
研究的目的:
- 确定过去26年的研究是否导致子宫内膜癌的种族差异显著改善.
- 分析发病率,存活率,预后因素,并发病,治疗,社会经济因素和分子标记的趋势.
- 确定可行的建议,以减轻日益扩大的差距.
主要方法:
- 从1997年到2023年,对英语出版物的快速系统审查.
- 专注于非洲裔美国妇女 (AAW) 和白人美国妇女 (WAW) 之间的子宫内膜癌的种族差异.
- 检查了发病率,存活率,预后变量,并发病,治疗,社会经济因素和分子标记.
主要成果:
- 与WAW相比,子宫内膜癌的发病率和死亡率在AAW中显著增加 (39%和26%,分别).
- 在AAW中,预后不良因素的流行率更高,并发病率更高,社会经济地位较低,治疗不足.
- 没有确定可操作的分子/遗传标记,也没有发现有效的政策实施策略.
结论:
- 26年来,子宫内膜癌发病率和死亡率的种族差异在AAW和WAW之间扩大.
- 目前的研究工作本身不足以消除这种差异.
- 提出了强有力的建议,以解决和减轻这种不断升级的健康不平等.
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