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基于迪克洛菲纳克支架的结构修改:通过选择性抑制COX-2/NLRP3来实现大肠炎副作用的减少

Zhiran Ju1, Junde Xu1, Keshuang Tang1

  • 1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, 310014, China.

European journal of medicinal chemistry
|February 21, 2024
PubMed
概括

合成了新的迪克洛菲纳克类似物,以准循环氧化酶-2 (COX-2) 和NOD,LRR和pyrin域含蛋白3 (NLRP3) 途径. 化合物6k显示出强大的抗炎作用和减少副作用,使其成为治疗炎症疾病的有希望的候选人.

关键词:
抗炎药物 抗炎药物 抗炎药物在COX-2中,COX-2是最常见的.狄克洛菲纳克 (Diclofenac) 是一种药物.在NLRP3中,NLRP3是NLRP3中的一个.性结肠炎是一种

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