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大脑和体连接器枢纽促进视觉和认知网络参与基本震
Epifanio Bagarinao1, Satoshi Maesawa2, Sachiko Kato3
1Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan; Brain and Mind Research Center, Nagoya University, Nagoya, Aichi, Japan.
Parkinsonism & related disorders
|February 21, 2024
概括
基本震涉及小脑和丘脑中大脑连接器枢纽的改变,影响感觉运动,视觉和认知网络. 这些变化与症状严重程度和治疗结果相关.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 临床神经学 临床神经学
背景情况:
- 连接器枢纽是关键的大脑区域,连接多个神经网络.
- 这些中心的功能障碍可能会影响各种神经系统.
- 基本震动的基础网络变化尚未完全理解.
研究的目的:
- 研究连接器枢纽在基本震病理生理学中的作用.
- 确定特定的枢纽区域及其网络连接受到重要震动的影响.
主要方法:
- 休息状态功能性MRI被用于分析27名基本震患者和27名对照者的全脑功能连接.
- 使用功能连接重叠比率来识别受影响的连接器集线器.
- 评估了枢纽连接,认知/震分数和治疗后运动改善之间的相关性.
主要成果:
- 小脑 (牙核) 和质体 (背中质体,脉) 中的连接器枢纽在基本震患者中显示出改变的连接性.
- 观察到这些枢纽与传感运动和视觉网络之间的连接性增加.
- 这些中心与认知网络的连接与治疗后的认知功能,震严重程度和运动改善有负相关性.
结论:
- 小脑和丘脑中的连接器枢纽与本质震有关,与感觉运动和视觉网络的连接性发生了变化.
- 这些广泛的连接可能代表了替代途径,并导致非运动症状.
- 枢纽与认知网络的连接与认知缺陷和基本震治疗反应有关.
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