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循环MicroRNA-19和心血管风险降低,以应对减肥饮食
Qiaochu Xue1, Yoriko Heianza1, Xiang Li1
1Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA.
Clinical nutrition (Edinburgh, Scotland)
|February 21, 2024
概括
在减肥期间循环中的microRNA-19 (miR-19) 水平降低与心血管疾病风险降低相关. 这些好处在睡眠障碍较少和体力活动增加的个体中得到了放大.
科学领域:
- 分子生物学分子生物学
- 心血管科学 心血管科学
- 代谢健康 代谢健康
背景情况:
- 微RNA-19 (miR-19) 与心脏发育和心血管疾病 (CVD) 有关.
- 在减肥干预期间循环miR-19水平与心血管疾病风险变化之间的关系需要研究.
研究的目的:
- 在24个月的减肥干预期间调查循环miR-19 (miR-19a-3p和miR-19b-3p) 和动脉样硬化心血管疾病 (ASCVD) 风险变化之间的关联.
- 探索睡眠障碍和体力活动对这种关联的修饰作用.
主要方法:
- 分析了509名超重/肥胖的参与者,这些参与者来自POUNDS Lost试验.
- 在基线和6个月的循环miR-19a-3p和miR-19b-3p的测量.
- 评估6个月和24个月ASCVD风险的变化,以及与睡眠和体力活动的相互作用分析.
主要成果:
- 在饮食干预的最初6个月内,循环中的miR-19a-3p和miR-19b-3p水平显著下降.
- 在6个月内,miR-19的较大下降独立地与更大的ASCVD风险降低有关.
- 显著的相互作用表明,在24个月内,减少miR-19与没有睡眠障碍和增加体力活动的个体中,与ASCVD风险降低有更强的联系.
结论:
- 在减肥干预期间循环miR-19水平降低与ASCVD风险降低有关.
- 减少miR-19和ASCVD风险之间的有益关联在没有睡眠障碍和增加体力活动的个体中更为明显.
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