相关实验视频

Updated: Jul 2, 2025

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo

Published on: August 2, 2017

妊娠年龄相关的尿变化在早产和早产婴儿中

Maire Brasseler¹, Harald Mischak², Joost P Schanstra^3,4

¹Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology and Centre for Translational and Behavioral Sciences (C-TNBS), University of Duisburg-Essen, Essen, Germany.

|February 21, 2024

概括

在早产婴儿的妊娠年龄随之改变的尿层模式. 这项研究确定了年龄相关的尿变化,为早产婴儿的新生预后生物标志物提供了潜力.

科学领域:

生物化学生物化学
新生儿科学新生儿科学
蛋白质组学是指蛋白质组学.

背景情况:

过早出生的婴儿面临体质和神经系统疾病的风险.
生物流体蛋白质组学是生物标志物分析的一个新兴工具.

研究的目的:

为了研究早产婴儿中与妊娠年龄 (GA) 相关的尿路形模式.
识别早产婴儿潜在的新型预后生物标志物.

主要方法:

在24名早产婴儿和27名早产婴儿的纵向样本上进行了尿学.
毛细电泳质谱法 (CE-MS) 和MS/MS用于分析.
统计分析将丰度和相关发现与GA和临床风险得分进行了比较.

主要成果:

在早产婴儿和早产婴儿之间观察到丰度的显著差异.
确认了尿层的年龄相关变化.
溶解物载体家族38成员10 (SLC38A10) 在早产婴儿中很丰富.
结合性尿与临床风险得分相关.

结论:

这是第一个使用CE-MS的早产婴儿报告GA相关的尿变化的研究.
需要进行进一步的研究,以将体群与临床并发症和长期结果相关联.
识别高风险的早产婴儿可能会使早期干预成为可能.

关键词:

生物标志物生物标志物正常值是指正常值的值.类组学类组学类组学过早出生的婴儿是早产的尿液尿液尿液

更多相关视频

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Neurodevelopmental Reflex Testing in Neonatal Rat Pups

Published on: April 24, 2017

Proteomic Profile of EPS-Urine through FASP Digestion and Data-Independent Analysis

Published on: May 8, 2021

相关概念视频

Teratogenicity

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...