在焦虑障碍中使用抗精神病药物:总体综述
Amir Garakani1,2, Frank D Buono2, Mona Salehi3
1Department of Psychiatry and Behavioral Health, Greenwich Hospital, Greenwich, Connecticut, USA.
Acta psychiatrica Scandinavica
|February 21, 2024
概括
这一综合性审查发现抗精神病药物在焦虑障碍中存在有限的证据,只有奎胺显示出对泛性焦虑障碍 (GAD) 的潜力. 由于研究的局限性和潜在风险,需要更多高质量的研究.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 基于证据的医学 基于证据的医学
背景情况:
- 第一代抗精神病药物 (FGA) 和第二代抗精神病药物 (SGA) 有时用于非标签的焦虑症,尽管批准有限.
- 现有的系统性审查往往侧重于SGA,需要更广泛的评估.
研究的目的:
- 评估FGA和SGA作为焦虑障碍辅助治疗的疗效.
- 为了比较抗精神病单一治疗与一线焦虑障碍治疗的有效性,风险和副作用.
主要方法:
- 采用总体审查方法,搜索多个数据库进行系统审查和元分析.
- 评估质量是使用A MeaSurement工具来评估系统性审查 (AMSTAR-2) 尺度进行评估的.
- 搜索被更新到2023年1月.
主要成果:
- 在包括的25个系统评价中,大多数是低质量的,只有一个被认为是高质量的.
- 与一线治疗相比,抗精神病单一治疗的证据不足,原因是研究设计有缺陷,样本大小小小.
- 有限的证据表明抗精神病药物的有效性,特别是氨酸,在一般性焦虑障碍 (GAD) 中.
结论:
- 对抗精神病药物治疗焦虑障碍的高质量研究很少,除了在GAD中使用奎蒂亚平外.
- FGA和SGA的潜在风险和副作用可能会超过它们在焦虑障碍中的有效性.
- 需要进一步进行大规模的长期研究,以澄清抗精神病药物在焦虑症治疗中的作用.
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