来自莫林达 (Morinda officinalis How.) 的抗炎单烯
Yan Jiang1, Lu Chen1, Jia Zeng2
1School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China; Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou, 510006, China.
Phytochemistry
|February 21, 2024
概括
莫林达 (Morinda officinalis) 含有新型抗炎化合物,可以抑制关键的炎症途径. 适度饮食可能有助于预防炎症性疾病.
科学领域:
- 植物化学 植物化学
- 药理学 药理学是指药理学的学科.
- 免疫学 免疫学 免疫学
背景情况:
- Morinda officinalis被公认为具有促进健康的功能的功能性食品.
- 炎症是许多慢性疾病的关键因素.
研究的目的:
- 为了研究Morinda officinalis中存在的抗炎植物化学物质.
- 从植物中分离和描述新型单烯.
- 评估隔离化合物的抗炎潜力.
主要方法:
- 使用HR-ESI-MS,NMR和ECD数据对单烯的隔离和结构阐明.
- 通过测量脂多糖糖诱导的RAW 264.7巨细胞中氧化产生的抗炎活性来评估抗炎活性.
- 对作用机制的分析,包括核因子-kappa B (NF-κB) 转位和炎症性细胞因子表达.
主要成果:
- 他们分离了30种单烯,其中包括6种新的虹和2种新的非循环单烯.
- 化合物11,12和20显示显著抑制氧化的产生.
- 发现这些活性化合物阻断NF-κB核转位,并降低炎症性细胞因子表达的调节.
结论:
- 莫林达 (Morinda officinalis) 具有强大的抗炎化合物,包括新型单烯.
- 已识别的化合物通过调节关键的炎症信号通路,产生抗炎作用.
- 这些发现支持Morinda officinalis的传统使用,并表明其在治疗炎症疾病方面的潜力.
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