内源性血栓激素潜力和时间依赖的血栓激素生成参数是一般人口死亡率的独立风险因素
Romy de Laat-Kremers1, Simona Costanzo2, Mark Roest3
1Department of Data Analysis and Artificial Intelligence, Synapse Research Institute, Maastricht, The Netherlands.
Journal of thrombosis and haemostasis : JTH
|February 21, 2024
概括
低内源性血栓激素潜力 (ETP) 和高时间到高峰到延迟时间比率是一般人群全因死亡率的独立风险因素,表明血栓形成风险增加.
科学领域:
- 血液静止和血栓形成研究
- 临床凝血诊断诊断 临床凝血诊断
- 对死亡风险的流行病学研究
背景情况:
- 血栓生成 (TG) 是凝血的一个关键的全球衡量标准.
- TG作为血栓形成和出血风险的指标.
- 之前关于TG和死亡率相关性的数据仍然没有确定性.
研究的目的:
- 调查血栓生成参数与死亡率之间的关联.
- 在一个大型前性队列中分析TG (Moli-sani,n=21,920).
主要方法:
- 校准自动血栓造影被用于测量TG.
- 量化的关键TG参数包括滞后时间 (LT),内源性血栓激素潜力 (ETP),峰值高度,到峰值时间 (TTP) 和速度指数.
- 使用考克斯回归分析来评估TG与死亡率之间的关联,以多个共同变量进行调整.
主要成果:
- 低ETP显著与所有原因死亡率的增加有关 (HR 0.86).
- 最低ETP五分位数 (ETPQ1) 的受试者表现出1.3倍高的死亡率.
- 高TTP/LT比率也与死亡率 (HR 0.71) 有负相关性,五分位数1显示死亡率高出1.4倍.
- 低ETP和高TTP/LT比率的结合表明死亡率高出1.8倍,而不管心血管疾病的病史.
结论:
- 减少ETP和提高TTP/LT比率被确定为所有原因死亡的独立风险因素.
- 这些发现强调了特定的TG参数作为一般人口死亡风险的有价值指标.
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