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Updated: Jul 2, 2025

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
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RANK/RANKL轴通过激活NF-κB通路促进骨髓瘤的迁移,入侵和转移

Tomoya Takeda1, Masanobu Tsubaki1, Shuji Genno1

  • 1Division of Pharmacotherapy, Kindai University School of Pharmacy, 3-4-1 Kowakae, Higashi-Osaka, Osaka, 577-8502, Japan.

Experimental cell research
|February 21, 2024
PubMed
概括

该RANK/RANKL通路通过诱导上皮细胞到介质细胞过渡 (EMT) 来促进骨髓瘤 (OS) 转移. NF-κB抑制剂二甲基烟酸 (DMF) 抑制了这种攻击性行为,这表明了潜在的治疗应用.

关键词:
(DMF) 的使用情况.(EMT) 的时间.(NF-κB) 的时间.(OS) 是一个操作系统.(等级) 的情况.甲基二甲烟酸二甲烟酸二甲烟酸二甲烟酸二甲烟酸二甲皮质-介质细胞过渡.肺部转移 肺部转移 肺部转移核因子-卡帕 B B 的核因子.骨质肉瘤骨质肉瘤是什么核因子kappa-BB的受体激活剂

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