核桃饼干诊断算法和预测果和核桃合过敏的验证
Michael R Goldberg1, Michael Y Appel2, Katz Tobi2
1Institute of Allergy, Immunology and Pediatric Pulmonology, Shamir (Assaf-Harofeh) Medical Center, Zerifin, Israel; Department of Pediatrics, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
The journal of allergy and clinical immunology. In practice
|February 21, 2024
概括
坚果饼干算法有效验证了果仁和 pistachio 的过敏诊断,显著减少了口服食品挑战的需要. 这种诊断工具还确定了严重性标志物,有可能改善树核过敏的口服免疫治疗方案.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 诊断算法 诊断算法
- 食物过敏研究 食物过敏研究
背景情况:
- 树核中的高交叉反应性需要有效的诊断方法.
- 坚果饼干研究之前提出了一个诊断算法,以尽量减少口服食品挑战 (OFC).
研究的目的:
- 为了验证坚果饼干诊断算法对果仁和 pistachio 过敏.
- 为了确定树核过敏的临床严重性标志物.
主要方法:
- 使用决策树算法对125名怀疑树核过敏的患者进行前性评估.
- 算法点包括皮肤刺伤测试 (SPT),基细胞激活测试 (BAT) 和共同过敏数据.
- 过敏状态被OFC证实;严重性标志物被使用SPT,BAT和特定IgE (sIgE) 评估到Ana o 3.
主要成果:
- 该算法将OFCs降低了72.0%,具有高正值 (93.0%) 和负值 (99.0%) 的预测值.
- 与单个果仁过敏患者相比,双重果仁/核桃过敏患者在SPT,BAT和Anao 3-sIgE中表现出更高的反应性.
- 对于诊断果过敏,Ana o 3-sIgE的灵敏度超过90%,特异性超过95%.
结论:
- 坚果饼干诊断算法已被验证为果仁和 pistachio 过敏,显著减少所需的 OFCs 的数量.
- 鉴定的严重性标志物可以告知口服免疫疗法,提高患者的风险/益处比率.
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