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与PD-1/PD-L1抑制剂相关的低血炎:来自FAERS数据库的分析和病例报告

Shanshan Chen¹, Linqi Ouyang², Lian Li³

¹Department of Pharmacy, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Drug discoveries & therapeutics

|February 21, 2024

概括

布罗利祖马布和尼沃卢马布可以引起低炎,这是一个罕见但严重的副作用. 这种情况,PD-1/L1抑制剂相关的低血炎,在老年男性中更为常见,需要及时的医疗照顾.

科学领域:

免疫学免疫学免疫学
内分泌学在内分泌学.
在瘤学瘤学.

背景情况:

免疫检查点抑制剂 (ICI),特别是PD-1/L1抑制剂,已经彻底改变了癌症治疗.
然而,免疫相关的不良事件 (irAEs) 可能会发生,包括缺血炎,影响垂体腺功能.

研究的目的:

综合性地描述PD-1/L1抑制剂相关的低性炎 (PD-1/L1-irH) 的临床特征.
为了确定PD-1/L1-irH的风险因素和临床表现模式.

主要方法:

对FDA不良事件报告系统 (FAERS) 的不成比例性分析.
追溯分析了84名PD-1/L1-irH患者的病例分析.
评估临床特征,发病时间,激素缺乏,治疗和结果.

主要成果:

在FAERS中检测到所有PD-1/L1抑制剂的显著的缺血炎信号.
在男性,PD-1抑制剂使用者和65岁以上的患者中,PD-1/L1-irH更常见.
中位发病时间为101天 (FAERS) 或8个周期 (病例分析);在停药后观察到晚发病例.
疲劳,厌食症,低血,低血压是常见的症状;孤立的ACTH缺乏症普遍存在 (85.71%).
报告指出,结果不佳:住院率为64.66%,死亡率为12.59%.
在PD-1/L1-irH诊断之前,在58.3%的患者中观察到有利的瘤反应.

结论:

PD-1/L1-irH可以在整个治疗过程中甚至在停止治疗后发生.
临床医生应监测PD-1抑制剂的使用者,特别是男性和老年患者.
早期诊断和及时治疗对于这种可能危及生命的疾病至关重要.

关键词:

这是一种PD-1/PD-L1抑制剂.这是一个特征性的特征.不成比例性分析分析低血压症是什么意思?管理层的管理层.

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