在幼儿中接种流感疫苗的最佳时间:基于人口的队列研究
Christopher M Worsham1,2,3, Charles F Bray1, Anupam B Jena4,2,5
1Department of Health Care Policy, Harvard Medical School, Boston, MA, USA.
BMJ (Clinical research ed.)
|February 21, 2024
概括
对幼儿的最佳流感疫苗接种时间至关重要. 10月份出生的孩子,在10月份接种疫苗,显示了最低的流感诊断率,支持早期疫苗接种.
科学领域:
- 儿童传染病 儿童传染病
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 建议儿童接种流感疫苗,以预防疾病.
- 小孩子接种流感疫苗的最佳时间仍然是研究领域.
- 疫苗接种时间表可能会受到诸如出生月份和预防性护理访问等因素的影响.
研究的目的:
- 评估幼儿流感疫苗接种的最佳时间.
- 调查出生月份,疫苗接种时间和流感诊断率之间的关联.
主要方法:
- 在美国,对2-5岁的商业保险儿童进行了基于人口的队列研究.
- 对2011-2018年流感疫苗接种日期和流感诊断率的分析.
- 准实验分析检查出生月份对疫苗接种时间和结果的影响.
主要成果:
- 超过80万名儿童接种了流感疫苗.
- 在11月和12月接种疫苗的儿童中,流感诊断率最低.
- 10月份出生的孩子更有可能在10月份接种疫苗,并且流感诊断率最低 (2.7%).
结论:
- 出生月份影响幼儿流感疫苗接种时间,主要是通过预防性护理访问.
- 10月份接种疫苗,特别是10月份出生的儿童,与流感诊断的减少有关.
- 这些发现支持了10月份流感疫苗接种的建议.
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The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
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The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
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