多发性硬化症中发作的发生率和决定因素:随机临床试验的元分析
Valeria Pozzilli1,2, Shalom Haggiag3, Massimiliano Di Filippo4
1Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Campus Bio-Medico University, Roma, Lazio, Italy.
Journal of neurology, neurosurgery, and psychiatry
|February 21, 2024
概括
多发性硬化症 (MS) 患者的发作发病率明显高于普通人群. 疾病的进展和某些药物,如斯芬戈-1-酸盐受体调节剂,会增加这种风险.
科学领域:
- 神经学 神经学
- 临床流行病学临床流行病学
背景情况:
- 发作在多发性硬化症 (MS) 患者中比一般人群更常见.
- 之前的研究依赖于人口数据,引入了偏见和可变性.
研究的目的:
- 在随机临床试验中确定多发性硬化症患者中发作的发生率.
- 确定导致MS中发作的因素.
主要方法:
- 一项对1993年至2022年间发表的60篇文章的元分析.
- 分析了53935名患者的数据,使用随机效应模型和元回归.
主要成果:
- 合并的发作发病率为每10万患者年68.0,是一般人口的两倍.
- 疾病进展,持续时间较长,残疾程度较高,大脑体积较低等因素与发作风险增加相关.
- 斯芬哥辛-1-酸盐受体 (S1PR) 调节器显示,发作风险增加了2.45倍.
结论:
- 多发性硬化症患者面临近两倍的发作风险.
- 发作风险与疾病负担和S1PR调节器使用有关.
- 是MS中显著的并发症,需要进一步研究触发因素和治疗方法.
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