无 NSAIDs 不能防止运动诱导的性能缺陷或缓解肌肉疼痛:一个安慰剂对照的随机,双盲,交叉研究
Brandon M Roberts1, Cara E Sczuroski1, Aaron R Caldwell2
1Military Performance Division, US Army Research Institute of Environmental Medicine, USA.
Journal of science and medicine in sport
|February 21, 2024
概括
运动员经常使用非类固醇抗炎药物 (NSAIDs) 治疗肌肉疼痛和表现. 预防性易布洛芬或弗鲁比没有显示任何益处,但塞莱科克西布可能会减少平度运动后的短期性能下降.
科学领域:
- 运动医学 运动医学
- 运动生理学 运动生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 非类固醇抗炎药物 (NSAIDs) 是运动员常用的,用于控制运动引起的肌肉疼痛,并提高恢复或表现.
- 对NSAIDs对肌肉疼痛和运动表现的预防作用仍然不完全理解.
- 了解这些影响对于指导安全有效的运动训练和恢复协议至关重要.
研究的目的:
- 为了研究预防性NSAID给药对肌肉疼痛和度运动后的表现的影响.
- 为了比较塞莱科克西布,易布洛芬和弗鲁比布洛芬在运动前服用的安慰剂的影响.
- 为了确定NSAID是否可以减轻与急性度训练相关的性能下降和不适.
主要方法:
- 一项随机,双盲,对抗平衡,交叉研究,涉及12名健康成年人 (18-42岁).
- 参与者在标准化压力计练习课程开始前2小时接受单剂量赛莱科西布 (200毫克),伊布洛芬 (800毫克),弗鲁比 (100毫克) 或安慰剂.
- 测量包括总工作量,感知劳力的评分,心率,最大自愿收缩力 (MVC),垂直跳跃高度和不同时间点的肌肉疼痛.
主要成果:
- 在治疗组之间,在总工作,心率或感知劳力的评级方面没有发现显著差异.
- 肌肉疼痛和垂直跳跃性能在NSAID和安慰剂治疗之间没有显著差异.
- 虽然易布洛芬和弗卢比芬无法阻止MVC的下降,但赛莱科克西布在运动后4小时显示有能力减轻MVC的下降.
结论:
- 预防性使用布洛芬或弗鲁比似乎对运动员在预防运动引起的不适或性能损失方面没有好处.
- 切莱科克西布可能通过减轻强度运动后最大自愿收缩力的性能下降来提供短期益处.
- 需要进一步的研究来探索NSAID在运动群体中使用的特定机制和长期影响.
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