相关实验视频

Updated: Jul 2, 2025

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts

Published on: May 25, 2018

在细胞癌中仅发生骨转移的自然史

Bixia Tang¹, Rong Duan², Zenan Fan²

¹Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Melanoma and Soft Tissue Sarcoma, Peking University Cancer Hospital & Institute, Beijing, China.

Urologic oncology

|February 21, 2024

概括

只有骨转移的细胞癌 (RCC) 患者表现出良好的预后. 转移部位数和IMDC评分等关键因素预测生存率,指导RCC骨转移的治疗决策.

科学领域:

在瘤学瘤学.
泌尿器科泌尿器科泌尿器科泌尿器科
癌症研究癌症研究

背景情况:

骨转移 (BM) 是细胞癌 (RCC) 的一个显著的负预后指标.
对于呈现仅骨转移的RCC患者的最佳管理策略,存在临床不确定性.

研究的目的:

分析细胞癌患者仅骨转移的临床结果和预后因素.
为了确定生存的预测因素,并在这个患者队列中告知治疗策略.

主要方法:

从2006年至2018年间治疗的54名连续RCC患者的仅骨转移的临床数据的回顾性分析.
基于转移负担 (oligo-vs. 多重转移) 和治疗方式的无进展生存 (PFS) 和总生存 (OS) 的评估.
单变量和多变量分析以确定显著的预后因素,包括转移部位的数量,IMDC得分和RCC病理亚型.

主要成果:

随访时间中位数为43.6个月,发现BM进展率或新的骨病变率为61.1%.
中位数PFS为16.2个月,中位数OS为65.2个月.
与多重转移 (>3位点) (42.0个月;P<0.001) 患者相比,患有橄转移 (≤3位点) 的患者的平均寿命 (未达到) 显著更好 (42.0个月;P<0.001).
转移部位的数量,IMDC得分和RCC病理亚型是预后的重要预测因素 (P < 0.05).

结论:

只有骨转移的细胞癌患者通常有良好的预后.
转移部位的数量,IMDC得分和RCC病理亚型是生存的关键预测因素.
这些预后因素可以指导选择适当的治疗方法来管理RCC骨转移.

关键词:

只有骨转移的转移.其他骨外转移的转移.辐射疗法辐射疗法细胞癌是细胞癌.系统性疗法是一种全身疗法.铁氨酸激酶抑制剂铁氨酸激酶抑制剂

更多相关视频

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

相关概念视频

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...