血清25-基维生素D调解重金属暴露与心血管疾病之间的关联
Yan Lu1, Licheng Lu2, Gang Zhang3,4
1Department of Cardiology, The People's Hospital of Suzhou New District, No.95 Huashan Road, Suzhou High-Tech Zone, Suzhou, Jiangsu, 215129, China.
BMC public health
|February 21, 2024
概括
25-氧维生素D (25(OH) D) 调解了暴露与心血管疾病 (CVD) 之间的关系. 增加维生素D摄入量可能会增强的含量.
科学领域:
- 环境健康 环境健康
- 营养流行病学 营养流行病学
- 心血管研究研究心血管研究
背景情况:
- 心血管疾病 (CVD) 是一个重要的全球健康问题.
- 接触重金属与包括心血管疾病在内的各种健康问题有关.
- 像25-基维生素D (25(OH) D这样的中间变量在调解这些关联中的作用需要进一步研究.
研究的目的:
- 评估血清25(OH) D在重金属暴露与心血管疾病之间的关联中的调解作用.
- 探索特定的重金属 (,,,,,),25 (OH) D水平和心血管疾病发病率之间的复杂关系.
主要方法:
- 利用了9377名参与国家健康和营养检查调查 (NHANES) (2011-2018) 的数据.
- 使用受限立方线 (RCS) 和多变量后勤回归来评估重金属-CVD和25(OH) D-CVD关联.
- 应用了通用的线性和添加物模型来研究重金属-25(OH) D相关性.
- 进行了调解分析,以确定25(OH) D对重金属-CVD通路的影响.
主要成果:
- 和显示出与心血管疾病的正线性关联;和显示出反向的线性关联.
- 和25(OH) D与心血管疾病有非线性 (L和U形) 的关系.
- 血清25(OH) D与,和有负相关性,与有正相关性.
- 在暴露和心血管疾病之间发现了25(OH) D的显著调解效应.
结论:
- 血清25(OH) D调解了暴露与发生心血管疾病之间的逆关系.
- 更高的维生素D摄入量可能会放大对心血管健康的保护作用.
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