通过降低MHC-I表达的调节,LATS1/2损失可以促进子宫内膜癌中的瘤免疫逃避

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Qianlan Yang1,2, Zehen Lv3,2, Mengfei Wang1,2

  • 1Department of Gynecology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.

Journal of experimental & clinical cancer research : CR
|February 21, 2024
PubMed
概括

在子宫内膜癌 (EC) 中的大型瘤抑制酶1/2 (LATS1/2) 损失通过降低主要基因相容性复合物I类 (MHC-I) 的调节促进免疫逃避. 恢复MHC-I表达可以逆转EC细胞对抗瘤免疫的抵抗力.

关键词:
这是子宫内膜癌的癌症.免疫逃逸是一种免疫逃避.在LATS1/2在MHC-I中,MHC-I是最重要的.美国国家统计局 (STAT1)

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