独特的肠道微生物特征与加速的全身和肠道生物衰老有关
Shalini Singh1, Leila B Giron1, Maliha W Shaikh2
1Vaccine and Immunotherapy Center, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA.
Microbiome
|February 21, 2024
概括
接受抗逆转录病毒疗法 (ART) 的艾滋病毒感染者 (PLWH) 在肠道和血液中表现出加速的生物衰老,这与肠道微生物变化和炎症有关. 了解这些微生物转变可能有助于对抗PLWH中与年龄相关的并发症.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 衰老研究研究 衰老研究
背景情况:
- 艾滋病毒感染者 (PLWH),即使在有效的抗逆转录病毒疗法 (ART) 上,也会经历持续的炎症,可能与肠道失调和微生物转移有关.
- 这种炎症可能会导致与艾滋病无关的老化并发症,但HIV和ART对肠道生物老化的影响尚不清楚.
- 微生物失调和转移在PLWH加速衰老中的特定作用需要进一步研究.
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