在COVID-19后的患者中,疲劳和基于症状的集群:多中心,前性,观察性队列研究
Merel E B Cornelissen1,2,3, Lizan D Bloemsma4,5,6, Anouk W Vaes7
1Department of Pulmonary Medicine, Amsterdam UMC, Amsterdam, The Netherlands. m.e.b.cornelissen@amsterdamumc.nl.
Journal of translational medicine
|February 21, 2024
概括
后COVID-19条件导致超过一半的患者持续疲劳和各种症状,许多患者符合肌痛性脑筋炎/慢性疲劳综合征标准. 症状模式与ME/CFS患者群体重叠.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 在荷兰,COVID-19后的病情影响12.7%的个人在感染后90-150天.
- 持续的症状会影响生活质量和医疗保健系统.
- 了解长期后果对于患者管理至关重要.
研究的目的:
- 为了确定后COVID-19患者的症状的发生和类型.
- 评估符合肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 标准的患者比例.
- 在COVID-19后的患者中识别症状集群,并将其与ME/CFS集群进行比较.
主要方法:
- 这是一项多中心,前性,观察性队列研究,对95名COVID-19后患者 (40-65岁) 进行了观察.
- 感染后3-6个月和9-12个月收集的数据,包括问卷 (疲劳严重程度表,DePaul症状问卷-2) 和医学检查.
- 使用自组织地图进行症状集群,将COVID-19后患者与先前建立的ME/CFS队列进行比较.
主要成果:
- 感染后3-6个月75.9%的人报告疲劳,感染后9-12个月57.1%的人报告疲劳.
- 运动后不适,睡眠障碍,疼痛和神经认知症状的高患病率.
- 52.7%满足了ME/CFS的福田标准;COVID-19后的患者出现在11个ME/CFS症状集群中,其中2个集群包含超过10名患者.
结论:
- 后COVID-19状态的特点是持续的疲劳和多种多样的症状,直至感染后18个月.
- 后COVID-19患者的症状概况与ME/CFS队列中的症状概况明显重叠.
- 需要进一步的研究来了解病理生理学和开发有针对性的治疗方法.
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