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Updated: Jul 2, 2025

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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针对T细胞恶性瘤中TRBC1和TRBC2的免疫疗法的结构导向工程

Mathieu Ferrari1, Matteo Righi1, Vania Baldan1

  • 1Autolus Therapeutics, London, UK.

Nature communications
|February 21, 2024
PubMed
概括

研究人员开发了针对T细胞受体常数域1和2 (TRBC1和TRBC2) 的新型抗体,用于T细胞恶性瘤. 这一突破使得针对缺乏明显癌症抗原的侵袭性淋巴瘤的新免疫疗法成为可能.

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