胆固醇基底前脑与基底侧杏仁体的连接调节食物摄入量
Joshua Ortiz-Guzman1,2,3, Jessica L Swanson2,3, Evelyne K Tantry2,3
1Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030.
eNeuro
|February 21, 2024
概括
研究人员发现,基础前脑胆性神经元 (BFc) 抑制食欲. 激活BFc神经元的作用
科学领域:
- 神经科学是一个神经科学.
- 养行为神经生物学
- 大脑电路和恒常状态.
背景情况:
- 由于过度进食而导致的肥胖是一个重大的公共卫生问题.
- 下丘脑是营养行为和体重调节的关键.
- 额外海马体电路也通过感官和奖励通路影响食欲.
研究的目的:
- 为了研究基底前脑胆能神经元 (BFc) 在食欲调节中的作用.
- 阐明通过BFc神经元影响养行为的神经电路.
主要方法:
- 在小鼠中利用病毒追踪来映射BFc神经元投射到底侧杏仁体 (BLA).
- 采用通道罗多普辛辅助电路映射来评估BLA中的胆反应.
- 在养期间在BLA中对乙胆和活性进行了体内成像.
- 使用光遗传学来操纵BFc-BLA信号,并观察食物摄入的影响.
主要成果:
- 发现BFc神经元密集地激发BLA,这是一个参与激发行为的区域.
- 来自BFc神经元的胆固醇信号在BLA神经元中引起了可测量的反应.
- 在体内成像显示了在养期间特定的BLA活动模式.
- 对BFc-BLA通路的光遗传激活抑制了食欲并减少了食物摄入.
结论:
- 从基底前脑到基底侧桃体的胆能信号直接抑制食欲.
- 这种BFc-BLA通路代表了一种新的神经电路,调节了食行为和体重恒温.
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