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Updated: Jul 2, 2025

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介质蛋白SYCP2通过R循环介导的DNA修复赋予了对破坏DNA的抗药性

Yumin Wang1, Boya Gao1,2, Luyuan Zhang3

  • 1Massachusetts General Hospital Cancer Center, Harvard Medical School, 13th Street, Charlestown, MA, 02129, USA.

Nature communications
|February 21, 2024
PubMed
概括

一种介质蛋白,SYCP2,在乳腺癌和卵巢癌中过度表达,通过增强DNA修复,驱动对DNA损伤反应 (DDR) 药物的耐药性. 准SYCP2可能会改善癌症治疗结果.

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