血清尿酸与NHANES 2011-2020男性骨矿物质密度之间的关联
Renwei Wang1, Yao Gao2, Peng Wang1
1Department of Orthopedic, Linfen Central Hospital, Linfen, 041000, China.
Scientific reports
|February 21, 2024
概括
血清尿酸 (SUA) 与美国男性的腰椎骨矿物质密度 (BMD) 有积极联系. 监测SUA可能有助于预测BMD,特别是在生长和衰老期间.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 公共卫生 公共卫生
背景情况:
- 在男性中,血清尿酸 (SUA) 和骨矿物质密度 (BMD) 之间的关联尚未得到充分证实.
- 了解这种关系对于不同生命阶段的骨健康管理至关重要.
研究的目的:
- 在一大群美国男性中,研究SUA水平和腰椎BMD之间的相关性.
- 根据SUA水平来确定监测骨健康的潜在临床影响.
主要方法:
- 来自国家健康和营养检查调查 (NHANES) (2011-2020) 的6254名美国男性 (12至80岁) 的数据分析.
- 血清尿酸 (SUA) 通过定时终点方法测量;用双能X射线吸收计 (DXA) 评估腰椎骨髓质量.
- 多变量线性回归模型调整了许多混因素,包括年龄,BMI,生活方式和血清分析物.
主要成果:
- 在SUA<5 mg/dL (β = 0.006,P <0.001) 的男性中,发现了SUA和腰椎骨髓 BMD 之间的显著正相关性.
- 与最低四分位数 (β = 0.020,P = 0.003) 的人相比,SUA最高四分位数的个体表现出0.020 g/cm2更高的腰椎 BMD.
结论:
- 血清尿酸 (SUA) 与美国男性的腰椎骨矿物质密度 (BMD) 在特定范围内正相关.
- 调查结果表明,SUA监测可以提供有关预测BMD的见解,特别是在骨发育和与年龄相关的骨损失的关键时期.
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