在大型社区监测研究中持续性SARS-CoV-2的流行
Mahan Ghafari1,2,3, Matthew Hall4,5, Tanya Golubchik4,6
1Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK. mahan.ghafari@ndm.ox.ac.uk.
Nature
|February 21, 2024
概括
持续的SARS-CoV-2感染可以作为新爆发的储存库,并导致长期的COVID. 这项研究确定了持续性感染,揭示了病毒演变和潜在的公共健康风险.
科学领域:
- 病毒学
- 流行病学
- 传染性疾病
背景情况:
- 持续的SARS-CoV-2感染可能成为病毒储存库,可能导致未来的疫情爆发并推动病毒的进化.
- 持续性SARS-CoV-2感染的患病率,病毒载荷动力学和进化动态尚不清楚.
研究的目的:
- 调查持续性SARS-CoV-2感染的流行情况,病毒载荷动力学和进化动态.
- 确定持续的SARS-CoV-2感染与急性COVID-19后续症状 (长期COVID) 之间的关联.
主要方法:
- 来自全国感染调查的病毒序列数据分析.
- 鉴定 SARS-CoV-2 RNA 在高位持续至少 30 和 60 天的人.
- 评估病毒氨基酸替代以推断进化的动态.
主要成果:
- 鉴定了381名持久性SARS-CoV-2感染者 (≥30天),其中54人持久性≥60天.
- 持续感染的个体报告长期COVID的几率超过50%.
- 估计有0.1-0.5%的感染变得持久,通常病毒载量反弹,并表现出不同的进化动态 (强或弱选择).
- 观察到与SARS-CoV-2变种,抗体点和免疫功能低下个体相关的突变.
结论:
- 持续的SARS-CoV-2感染是一个重大问题,可能会导致病毒储存,进化和长期COVID.
- 了解持续性感染对于管理SARS-CoV-2的流行病学和演变至关重要.
- 需要进一步的研究来充分描述持续的SARS-CoV-2复制的机制和影响.
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