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Updated: Jul 2, 2025

Global Identification of Co-Translational Interaction Networks by Selective Ribosome Profiling
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UFM1 E3酶识别并释放来自ER转位的60S核糖体

Linda Makhlouf1, Joshua J Peter2, Helge M Magnussen2

  • 1Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Nature
|February 21, 2024
PubMed
概括

UFM1核糖体E3连接酶 (UREL) 复合物修改停滞的核糖体,促进它们从ER膜释放. 这种UFMylation过程对蛋白质平衡至关重要,并且通过将它们与SEC61转位素分离而循环利用核糖体.

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