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Updated: Jul 2, 2025

Author Spotlight: Epigenetic Modifications and Metabolic Rewiring as Targets for Cancer Therapy
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在基因甲基化向治疗中的作用机制和耐药性

Makoto Yamagishi1,2, Yuta Kuze3, Seiichiro Kobayashi4,5

  • 1Laboratory of Viral Oncology and Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. myamagishi@edu.k.u-tokyo.ac.jp.

Nature
|February 21, 2024
PubMed
概括

通过改变染色质结构,Valemetostat是一种EZH1- EZH2抑制剂,在成年T细胞白血病/ 淋巴瘤中缩小瘤并显示持久反应. 通过突变或DNA甲基化出现抗药性,突显了持续的表观遗传癌症治疗的需要.

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