相关实验视频

Updated: May 11, 2026

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

Published on: March 8, 2014

多发性骨髓瘤患者血液的风湿学特性

Bartłomiej Ptaszek¹, Szymon Podsiadło², Zuzanna Jandziś³

¹Institute of Applied Sciences, University of Physical Education in Krakow, 31-571, Kraków, Poland. bartlomiej.ptaszek@awf.krakow.pl.

Scientific reports

|February 22, 2024

概括

多发性骨髓瘤患者表现出改变的红细胞聚合和可变性. 这些血液变化,包括较高的聚合指数,可能有助于诊断多发性骨髓瘤.

科学领域:

血液学血液学血液学
类风病学类风病学类风病学
在瘤学瘤学.

背景情况:

多发性骨髓瘤 (MM) 是一种血液性恶性瘤,其特征是异常的血细胞增殖.
诊断MM通常涉及各种血液检测,但血液病理学概况研究较少.
红细胞的变形和聚合对于维持适当的血液循环和组织氧化是至关重要的.

研究的目的:

为了比较多发性骨髓瘤患者与健康个体的血液类风湿学和红细胞形态学.
调查MM的血液病学参数内的潜在诊断标志物.

主要方法:

一项涉及33名MM患者和33名健康对照者的比较研究.
使用ABX MICROS 60分析仪分析的血液学参数.
用LORCA分析仪评估红细胞聚合和可变性.

主要成果:

MM患者的红细胞计数 (RBC) 和总聚合半衰期 (T1/2) 显著降低.
患有MM的患者显示出更高的平均体积 (MCV),聚合指数 (AI) 和总聚合程度 (AMP).
与对照组相比,MM患者的红细胞聚合量大约高出50%.

结论:

在MM患者和健康个体之间,红细胞聚合和可变性存在显著差异.
改变的血液学参数,特别是增加的细胞聚合,可以作为MM诊断的有价值的指标.
进一步研究红细胞形态和类风病学可能有助于怀疑MM的临床决策.

关键词:

血液类风湿学血液类风湿学多发性骨髓瘤是一种多发性骨髓瘤.红细胞是血液中的红细胞.红细胞聚合红细胞聚合红细胞的可变性红细胞的可变性

更多相关视频

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

相关概念视频

Characteristics and Functions of Blood

Characteristics and Functions of Blood

Blood is specialized connective tissue comprising about 8% of the body mass. It has a thick, liquid extracellular matrix that contains cells, dissolved proteins, and electrolytes, making it five times more viscous than water. Blood is warm, around 38°C, and has an alkaline pH ranging from 7.35 to 7.45.
The primary function of blood is to transport oxygen and carbon dioxide between tissues and the lungs. Oxygenated blood is bright red, while oxygen-depleted blood is darker. It also carries...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...